Evaluating the global prevalence of HPV16 and HPV18 in cervical lesions and normal cytology
The aim of this study is to investigate the global prevalence of HPV16 and HPV18 in cervical carcinoma, low-grade cervical lesions, high-grade cervical lesions, and normal cytology.
Objectives:
1. Determine the global prevalence of HPV16 and HPV18 in cervical carcinoma, low-grade cervical lesions, high-grade cervical lesions, and normal cytology.
2. Assess the distribution of HPV types, both globally and by geographical region, in cervical carcinoma, low-grade cervical lesions, high-grade cervical lesions, and normal cytology, based on the identified HPV DNA and genotyping techniques used in the studies.
Link: https://rpubs.com/Keletso_Phohlo/1180848
Detecting multifactorial drivers of STI and HPV co-infection using H2O AutoML
This study aims to identify the best machine learning algorithm within the H2O AutoML framework for predicting STI prevalence in South Africa, focusing on the Eastern Cape. The findings will enhance understanding of STIs in the region, informing targeted interventions and preventive strategies. This research seeks to reduce the burden of HPV infections on women's health in rural communities.
The primary objective of this study is to investigate the risk factors associated with high-risk (HR) HPV infection among women residing in the Eastern Cape Province of South Africa.
Link: https://rpubs.com/Keletso_Phohlo/1181947
Unveiling the Silent Epidemic: Global occult HBV prevalence in all ages
Introduction
Hepatitis B virus (HBV) causes hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC), posing a global threat despite immunization efforts. In 2019, 296 million people had chronic HBV, including 6 million children under five. Occult HBV infection (OBI), marked by HBV DNA presence in HBsAg-negative individuals, shares HBV’s oncogenic risks and may progress to HCC. Despite its transmission risks, especially in hyper-endemic regions, OBI remains underrecognized in global hepatitis elimination strategies.
This study aims to determine OBI prevalence worldwide across age groups, including children, adolescents, and adults.
Link: https://rpubs.com/Keletso_Phohlo/1179189
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